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Spectroscopic and Computational Characterization of the NO Adduct of Substrate-Bound Fe(II) Cysteine Dioxygenase: Insights into the Mechanism of O(2) Activation

Cysteine dioxygenase (CDO) is a mononuclear non-heme iron(II)-dependent enzyme critical for maintaining appropriate cysteine (Cys) and taurine levels in eukaryotic systems. Since CDO possesses both an unusual 3-His facial ligation sphere to the iron center and a rare Cys-Tyr crosslink near the activ...

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Main Authors: Blaesi, Elizabeth J., Gardner, Jessica D., Fox, Brian G., Brunold, Thomas C.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974268/
https://ncbi.nlm.nih.gov/pubmed/23906193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400825c
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