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Epigenetic plasticity of Cd8a locus during CD8(+) T-cell development and effector differentiation and reprogramming
Modulation of CD8 coreceptor levels can profoundly affect T-cell sensitivity to antigen. Here we show that the heritable downregulation of CD8 during type 2 polarization of murine CD8(+) effector T cells in vitro and in vivo is associated with CpG methylation of several regions of the Cd8a locus. Th...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Pub. Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3974221/ https://ncbi.nlm.nih.gov/pubmed/24675400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4547 |
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