Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo

Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) pheno...

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Detaylı Bibliyografya
Asıl Yazarlar: Olver, Stuart, Apte, Simon H, Baz, Adriana, Kelso, Anne, Kienzle, Norbert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2013
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3647185/
https://ncbi.nlm.nih.gov/pubmed/23311920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12068
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