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Interleukin-4-induced loss of CD8 expression and cytolytic function in effector CD8 T cells persists long term in vivo
Activation of naive CD8(+) T cells in the presence of interleukin-4 modulates their CD8 co-receptor expression and functional differentiation, resulting in the generation of CD8(low) cells that produce type 2 cytokines and display poor cytolytic and anti-tumour activity. Although this CD8(low) pheno...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Science Inc
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3647185/ https://ncbi.nlm.nih.gov/pubmed/23311920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12068 |
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