High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer

Leptomeningeal metastases (LM) occur in 5–10% of patients with solid tumors and are associated with a dismal prognosis. We describe LM from lung adenocarcinoma harboring a mutation in the epidermal growth factor receptor (EGFR) gene that confers sensitivity to the EGFR tyrosine kinase inhibitors (EG...

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Hauptverfasser: Clarke, Jennifer L., Pao, William, Wu, Nian, Miller, Vincent A., Lassman, Andrew B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973736/
https://ncbi.nlm.nih.gov/pubmed/20146086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-010-0128-6
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