“Pulsatile” high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer

Erlotinib is effective for epidermal growth factor receptor (EGFR) mutant lung cancer, but CNS penetration at standard daily dosing is limited. We previously reported that intermittent “pulsatile” administration of high-dose (1500 mg) erlotinib once weekly was tolerable and achieved concentrations i...

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Detalhes bibliográficos
Main Authors: Grommes, Christian, Oxnard, Geoffrey R., Kris, Mark G., Miller, Vincent A., Pao, William, Holodny, Andrei I., Clarke, Jennifer L., Lassman, Andrew B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223088/
https://ncbi.nlm.nih.gov/pubmed/21865399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor121
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