“Pulsatile” high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer

Erlotinib is effective for epidermal growth factor receptor (EGFR) mutant lung cancer, but CNS penetration at standard daily dosing is limited. We previously reported that intermittent “pulsatile” administration of high-dose (1500 mg) erlotinib once weekly was tolerable and achieved concentrations i...

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Bibliographic Details
Main Authors: Grommes, Christian, Oxnard, Geoffrey R., Kris, Mark G., Miller, Vincent A., Pao, William, Holodny, Andrei I., Clarke, Jennifer L., Lassman, Andrew B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
Subjects:
Clinical Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223088/
https://ncbi.nlm.nih.gov/pubmed/21865399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nor121
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