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A monoclonal immunotoxin acting on the Na+ channel, with properties similar to those of a scorpion toxin.
We describe the properties of a monoclonal antibody against the Na+ channel. The antibody, 72.38, competitively inhibited (Ki = 1.5 X 10(-9) M) the binding of an 125I-labeled toxin from the Brazilian scorpion Tityus serrulatus (125I-TiTX gamma) to Na+ channels of rat brain membranes. No significant...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1985
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2580299/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.6.1842 |
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