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A monoclonal immunotoxin acting on the Na+ channel, with properties similar to those of a scorpion toxin.

We describe the properties of a monoclonal antibody against the Na+ channel. The antibody, 72.38, competitively inhibited (Ki = 1.5 X 10(-9) M) the binding of an 125I-labeled toxin from the Brazilian scorpion Tityus serrulatus (125I-TiTX gamma) to Na+ channels of rat brain membranes. No significant...

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Bibliografiske detaljer
Main Authors: Barhanin, J, Meiri, H, Romey, G, Pauron, D, Lazdunski, M
Format: Artigo
Sprog:Inglês
Udgivet: 1985
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC397369/
https://ncbi.nlm.nih.gov/pubmed/2580299
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