Transport properties of pancreatic cancer describe gemcitabine delivery and response

Background. The therapeutic resistance of pancreatic ductal adenocarcinoma (PDAC) is partly ascribed to ineffective delivery of chemotherapy to cancer cells. We hypothesized that physical properties at vascular, extracellular, and cellular scales influence delivery of and response to gemcitabine-bas...

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Detalhes bibliográficos
Main Authors: Koay, Eugene J., Truty, Mark J., Cristini, Vittorio, Thomas, Ryan M., Chen, Rong, Chatterjee, Deyali, Kang, Ya’an, Bhosale, Priya R., Tamm, Eric P., Crane, Christopher H., Javle, Milind, Katz, Matthew H., Gottumukkala, Vijaya N., Rozner, Marc A., Shen, Haifa, Lee, Jeffery E., Wang, Huamin, Chen, Yuling, Plunkett, William, Abbruzzese, James L., Wolff, Robert A., Varadhachary, Gauri R., Ferrari, Mauro, Fleming, Jason B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973100/
https://ncbi.nlm.nih.gov/pubmed/24614108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73455
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