Transport properties of pancreatic cancer describe gemcitabine delivery and response

Background. The therapeutic resistance of pancreatic ductal adenocarcinoma (PDAC) is partly ascribed to ineffective delivery of chemotherapy to cancer cells. We hypothesized that physical properties at vascular, extracellular, and cellular scales influence delivery of and response to gemcitabine-bas...

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Hlavní autoři: Koay, Eugene J., Truty, Mark J., Cristini, Vittorio, Thomas, Ryan M., Chen, Rong, Chatterjee, Deyali, Kang, Ya’an, Bhosale, Priya R., Tamm, Eric P., Crane, Christopher H., Javle, Milind, Katz, Matthew H., Gottumukkala, Vijaya N., Rozner, Marc A., Shen, Haifa, Lee, Jeffery E., Wang, Huamin, Chen, Yuling, Plunkett, William, Abbruzzese, James L., Wolff, Robert A., Varadhachary, Gauri R., Ferrari, Mauro, Fleming, Jason B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
Témata:
Clinical Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3973100/
https://ncbi.nlm.nih.gov/pubmed/24614108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI73455
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