Single Nucleotide Polymorphisms of Gemcitabine Metabolic Genes and Pancreatic Cancer Survival and Drug Toxicity

PURPOSE: To demonstrate whether single nucleotide polymorphisms (SNPs) of drug metabolic genes were associated with toxicity of gemcitabine-based chemoradiotherapy and overall survival (OS) of patients with pancreatic cancer. EXPERIMENTAL DESIGN: We evaluated 17 SNPs of the CDA, dCK, DCTP, RRM1, hCN...

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Bibliographic Details
Main Authors: Okazaki, Taro, Javle, Milind, Tanaka, Motofumi, Abbruzzese, James L., Li, Donghui
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2802655/
https://ncbi.nlm.nih.gov/pubmed/20028759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-1555
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