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Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.

The drug 5-azacytidine was injected into mice to activate silent retroviral genomes. The Mov-7 and Mov-10 substrains of mice were used, each of which carries a Moloney murine leukemia provirus with mutations in the coding regions at nonidentical positions. These proviral genomes are highly methylate...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Jaenisch, R, Schnieke, A, Harbers, K
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1985
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397280/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2579397/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1451
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