Treatment of mice with 5-azacytidine efficiently activates silent retroviral genomes in different tissues.
The drug 5-azacytidine was injected into mice to activate silent retroviral genomes. The Mov-7 and Mov-10 substrains of mice were used, each of which carries a Moloney murine leukemia provirus with mutations in the coding regions at nonidentical positions. These proviral genomes are highly methylate...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1985
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397280/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2579397/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1451 |
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