A fidelity assay using "dideoxy" DNA sequencing: a measurement of sequence dependence and frequency of forming 5-bromouracil X guanine base mispairs.

DNA replication fidelity has been assayed by using a modified DNA sequencing reaction. In one experimental approach, dideoxycytidine 5'-triphosphate (ddCTP) was used as a chain terminator during replication of M13 phage DNA by the large fragment of DNA polymerase I. The deoxyribonucleotide analogue...

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Yayımlandı:	Proc Natl Acad Sci U S A
Asıl Yazarlar:	Lasken, R S, Goodman, M F
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	National Academy of Sciences 1985
Konular:	Research Article
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC397248/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3856263/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.82.5.1301
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