Klotho has dual protective effects on cisplatin-induced acute kidney injury

Klotho protects the kidney from ischemia-reperfusion injury, but its effect on nephrotoxins is unknown. Here we determined if Klotho protects the kidney from cisplatin toxicity. Cisplatin increased plasma creatinine and induced tubular injury, which were exaggerated in Klotho haplosufficient (Kl/+)...

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Bibliographic Details
Main Authors: Panesso, Monica Chang, Shi, Mingjun, Cho, Han Ju, Paek, Jean, Ye, Jianfeng, Moe, Orson W., Hu, Ming Chang
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972320/
https://ncbi.nlm.nih.gov/pubmed/24304882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.489
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