VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation

Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism of such anticancer effects remains incompletely understood. In this study,...

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Autori principali: Zhang, Yan-Ting, Xu, Li-Hui, Lu, Qun, Liu, Kun-Peng, Liu, Pei-Yan, Ji, Fang, Liu, Xiao-Ming, Ouyang, Dong-Yun, He, Xian-Hui
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972149/
https://ncbi.nlm.nih.gov/pubmed/24691407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093547
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