VASP Activation via the Gα13/RhoA/PKA Pathway Mediates Cucurbitacin-B-Induced Actin Aggregation and Cofilin-Actin Rod Formation

Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis. However, the underlying molecular mechanism of such anticancer effects remains incompletely understood. In this study,...

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Detalhes bibliográficos
Main Authors: Zhang, Yan-Ting, Xu, Li-Hui, Lu, Qun, Liu, Kun-Peng, Liu, Pei-Yan, Ji, Fang, Liu, Xiao-Ming, Ouyang, Dong-Yun, He, Xian-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972149/
https://ncbi.nlm.nih.gov/pubmed/24691407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093547
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