Base Excision Repair of Chemotherapeutically-Induced Alkylated DNA Damage Predominantly Causes Contractions of Expanded GAA Repeats Associated with Friedreich's Ataxia

Expansion of GAA·TTC repeats within the first intron of the frataxin gene is the cause of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative disorder. However, no effective treatment for the disease has been developed as yet. In this study, we explored a possibility of shorten...

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Detalhes bibliográficos
Main Authors: Lai, Yanhao, Beaver, Jill M., Lorente, Karla, Melo, Jonathan, Ramjagsingh, Shyama, Agoulnik, Irina U., Zhang, Zunzhen, Liu, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3972099/
https://ncbi.nlm.nih.gov/pubmed/24691413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093464
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