Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C-α

[Image: see text] Protein kinase C-α (PKCα) is a member of the conventional family of protein kinase C isoforms (cPKCs) that regulate diverse cellular signaling pathways, share a common activation mechanism, and are linked to multiple pathologies. The cPKC domain structure is modular, consisting of...

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Bibliographic Details
Main Authors: Ziemba, Brian P., Li, Jianing, Landgraf, Kyle E., Knight, Jefferson D., Voth, Gregory A., Falke, Joseph J.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971957/
https://ncbi.nlm.nih.gov/pubmed/24559055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4016082
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