Interference with Akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress

The intricacy of multiple feedback loops in the pathways downstream of Akt allows Akt to control multiple cellular processes in the cardiovascular system and precludes inferring consequences of its activation in specific pathological conditions. Akt1, the major Akt isoform in heart and vasculature,...

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Main Authors: Kerr, Bethany A., Ma, Lining, West, Xiaoxia Z., Ding, Liang, Malinin, Nikolay L., Weber, Malory E., Tischenko, Mira, Goc, Anna, Somanath, Payaningal R., Penn, Marc S., Podrez, Eugene A., Byzova, Tatiana V.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971949/
https://ncbi.nlm.nih.gov/pubmed/23921086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003948
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