Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

Mutations in PINK1 and Parkin are associated with early-onset Parkinson's disease. We recently discovered that PINK1 phosphorylates Parkin at serine65 (Ser(65)) within its Ubl domain, leading to its activation in a substrate-free activity assay. We now demonstrate the critical requirement of Se...

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Bibliografiske detaljer
Main Authors: Kazlauskaite, Agne, Kelly, Van, Johnson, Clare, Baillie, Carla, Hastie, C. James, Peggie, Mark, Macartney, Thomas, Woodroof, Helen I., Alessi, Dario R., Pedrioli, Patrick G. A., Muqit, Miratul M. K.
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971407/
https://ncbi.nlm.nih.gov/pubmed/24647965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.130213
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