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Tuning up the right signal: chemical and genetic approaches to study GPCR functions

The G protein-coupled receptor (GPCR) family is among the most druggable families in the human proteome. GPCRs are involved in most physiological processes, and our ability to modulate their activity is a hallmark of modern pharmacology. The means by which the activity of GPCRs can be modulated have...

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Autors principals: Giguere, Patrick M., Kroeze, Wesley K., Roth, Bryan L.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3971376/
https://ncbi.nlm.nih.gov/pubmed/24680430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2013.11.006
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