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A conserved MCM single-stranded DNA binding element is essential for replication initiation

The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular d...

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Detalhes bibliográficos
Main Authors: Froelich, Clifford A, Kang, Sukhyun, Epling, Leslie B, Bell, Stephen P, Enemark, Eric J
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970758/
https://ncbi.nlm.nih.gov/pubmed/24692448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01993
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