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DNA translocation mechanism of the MCM complex and implications for replication initiation

The DNA translocation activity of the minichromosome maintenance (MCM) complex powers DNA strand separation of the replication forks of eukaryotes and archaea. Here we illustrate an atomic level mechanism for this activity with a crystal structure of an archaeal MCM hexamer bound to single-stranded...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Meagher, Martin, Epling, Leslie B., Enemark, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629641/
https://ncbi.nlm.nih.gov/pubmed/31308367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11074-3
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