MCM ring hexamerization is a prerequisite for DNA-binding

The hexameric Minichromosome Maintenance (MCM) protein complex forms a ring that unwinds DNA at the replication fork in eukaryotes and archaea. Our recent crystal structure of an archaeal MCM N-terminal domain bound to single-stranded DNA (ssDNA) revealed ssDNA associating across tight subunit inter...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Froelich, Clifford A., Nourse, Amanda, Enemark, Eric J.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627082/
https://ncbi.nlm.nih.gov/pubmed/26365238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv914
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