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Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist
The concepts of allosteric modulation and biased agonism are revolutionizing modern approaches to drug discovery, particularly in the field of G protein-coupled receptors (GPCRs). Both phenomena exploit topographically distinct binding sites to promote unique GPCR conformations that can lead to diff...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970544/ https://ncbi.nlm.nih.gov/pubmed/24619092 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320962111 |
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