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Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

Why does cancer risk increase as we age? Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations, this question is a matter of ongoing debate. Here, we propose that the normal decline in oxidative metabolism during aging constitutes an early and import...

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Hlavní autoři: Wu, Lindsay E., Gomes, Ana P., Sinclair, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970212/
https://ncbi.nlm.nih.gov/pubmed/24434207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.12.005
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