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Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis
Why does cancer risk increase as we age? Frequently attributed to the multi-hit hypothesis and the time required to accumulate genomic mutations, this question is a matter of ongoing debate. Here, we propose that the normal decline in oxidative metabolism during aging constitutes an early and import...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3970212/ https://ncbi.nlm.nih.gov/pubmed/24434207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.12.005 |
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