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Hematological, Hepatic, and Retinal Phenotypes in Mice Deficient for Prolyl Hydroxylase Domain Proteins in the Liver

Prolyl hydroxylase domain (PHD) proteins catalyze oxygen-dependent prolyl hydroxylation of hypoxia-inducible factor 1α and 2α, tagging them for pVHL-dependent polyubiquitination and proteasomal degradation. In this study, albumin Cre (Alb(Cre))–mediated, hepatocyte-specific triple disruption of Phd1...

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書誌詳細
主要な著者: Duan, Li-Juan, Takeda, Kotaro, Fong, Guo-Hua
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Investigative Pathology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3970000/
https://ncbi.nlm.nih.gov/pubmed/24508125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.12.014
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