E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation

E3 ubiquitin ligase Cbl-b has emerged as a gatekeeper that controls the activation threshold of the T cell antigen receptor and maintains the balance between tolerance and autoimmunity. Here, we report that the loss of Cbl-b facilitates T helper 2 (Th2) and Th9 cell differentiation in vitro. In a mo...

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Main Authors: Qiao, Guilin, Ying, Haiyan, Zhao, Yixia, Liang, Yanran, Guo, Hui, Shen, Huifeng, Li, Zhenping, Solway, Julian, Tao, Enxiang, Chiang, Y. Jeffrey, Lipkowitz, Stanley, Penninger, Josef M., Langdon, Wallace Y., Zhang, Jian
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3969736/
https://ncbi.nlm.nih.gov/pubmed/24508458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.012
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