Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively‐activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells

Constitutively‐activated JAK/Stat3 or Src/Stat3 signaling plays a crucial role in tumor cell survival, proliferation, angiogenesis and immune suppression. Activated JAK/Stat3 or Src/Stat3 has been validated as a promising molecular target for cancer therapy. However, prolonged inhibition of Src fami...

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Autors principals: Nam, Sangkil, Wen, Wei, Schroeder, Anne, Herrmann, Andreas, Yu, Hua, Cheng, Xinlai, Merz, Karl-Heinz, Eisenbrand, Gerhard, Li, Hongzhi, Yuan, Yate-Ching, Jove, Richard
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2012
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Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968804/
https://ncbi.nlm.nih.gov/pubmed/23206899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2012.10.013
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