Protective Immunity and Defects in the Neonatal and Elderly Immune Response to Sepsis

Populations encompassing extremes of age, including neonates and elderly, have greater mortality from sepsis. We propose that the increased mortality observed in the neonatal and elderly populations after sepsis is due to fundamental differences in host protective immunity, and are manifested at the...

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Hauptverfasser: Gentile, Lori F., Nacionales, Dina C., Lopez, M. Cecilia, Vanzant, Erin, Cuenca, Angela, Cuenca, Alex G., Ungaro, Ricardo, Szpila, Ben E., Larson, Shawn, Joseph, Anna, Moore, Frederick, Leeuwenburgh, Christiaan, Baker, Henry V., Moldawer, Lyle L., Efron, Philip A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967513/
https://ncbi.nlm.nih.gov/pubmed/24591376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301726
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