OSTEOPONTIN BINDING TO LIPOPOLYSACCHARIDE LOWERS TUMOR NECROSIS FACTOR-α AND PREVENTS EARLY ALCOHOL-INDUCED LIVER INJURY IN MICE

RATIONALE: Although osteopontin (OPN) is induced in alcoholic patients, its role in the pathophysiology of alcoholic liver disease (ALD) remains unclear. Increased translocation of lipopolysaccharide (LPS) from the gut is key for the onset of ALD since it promotes macrophage infiltration and activat...

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Hlavní autoři: Ge, Xiaodong, Leung, Tung-Ming, Arriazu, Elena, Lu, Yongke, Urtasun, Raquel, Christensen, Brian, Fiel, Maria Isabel, Mochida, Satoshi, Sørensen, Esben S., Nieto, Natalia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966944/
https://ncbi.nlm.nih.gov/pubmed/24214181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26931
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