Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury

OBJECTIVE: Liver fibrosis is associated with significant collagen-I deposition largely produced by activated hepatic stellate cells (HSCs); yet, the link between hepatocyte damage and the HSC profibrogenic response remains unclear. Here we show significant induction of osteopontin (OPN) and high-mob...

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Bibliographic Details
Published in:Gut
Main Authors: Arriazu, Elena, Ge, Xiaodong, Leung, Tung-Ming, Magdaleno, Fernando, Lopategi, Aritz, Lu, Yongke, Kitamura, Naoto, Urtasun, Raquel, Theise, Neil, Antoine, Daniel J, Nieto, Natalia
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2017
Subjects:
Hepatology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532463/
https://ncbi.nlm.nih.gov/pubmed/26818617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310752
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