Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease

The aim of this study was to investigate the role of osteopontin (OPN) in hematopoietic stem cell (HPSC) mobilization to the liver and its contribution to alcoholic liver disease (ALD). We analyzed young (14‐16 weeks) and old (>1.5 years) wild‐type (WT) littermates and global Opn knockout (Opn(−/...

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Vydáno v:Hepatol Commun
Hlavní autoři: Magdaleno, Fernando, Ge, Xiaodong, Fey, Holger, Lu, Yongke, Gaskell, Harriet, Blajszczak, Chuck C., Aloman, Costica, Fiel, M. Isabel, Nieto, Natalia
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5776866/
https://ncbi.nlm.nih.gov/pubmed/29404515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep4.1116
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