Probenecid Blocks Human P2X7 Receptor-Induced Dye Uptake via a Pannexin-1 Independent Mechanism

P2X7 is a ligand-gated ion channel which is activated by ATP and displays secondary permeability characteristics. The mechanism of development of the secondary permeability pathway is currently unclear, although a role for the hemichannel protein pannexin-1 has been suggested. In this study we inves...

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Main Authors: Bhaskaracharya, Archana, Dao-Ung, Phuong, Jalilian, Iman, Spildrejorde, Mari, Skarratt, Kristen K., Fuller, Stephen J., Sluyter, Ronald, Stokes, Leanne
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966854/
https://ncbi.nlm.nih.gov/pubmed/24671093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0093058
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