In vivo effects of the pure aryl hydrocarbon receptor antagonist GNF-351 after oral administration are limited to the gastrointestinal tract

BACKGROUND AND PURPOSE: GNF-351 is a potent aryl hydrocarbon receptor (AHR) antagonist that inhibits dioxin response element-dependent and independent activities. Here, the absorption, metabolism and in vivo AHR antagonist activity of GNF-351 were investigated. EXPERIMENTAL APPROACH: LC-MS metabolom...

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Bibliografische gegevens
Hoofdauteurs: Fang, Zhong-Ze, Krausz, Kristopher W, Nagaoka, Kenjiro, Tanaka, Naoki, Gowda, Krishne, Amin, Shantu G, Perdew, Gary H, Gonzalez, Frank J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2014
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966752/
https://ncbi.nlm.nih.gov/pubmed/24417285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12576
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