Aryl Hydrocarbon Receptor Antagonism Attenuates Growth Factor Expression, Proliferation, and Migration in Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disease with high morbidity and mortality. Within the inflammatory milieu, resident fibroblast-like synoviocytes (FLS) in the synovial tissue undergo hyperplasia, which leads to joint destruction. Epidemiologic studies and our previous research sugge...

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Main Authors: Lahoti, Tejas S., Hughes, Jarod M., Kusnadi, Ann, John, Kaarthik, Zhu, Bokai, Murray, Iain A., Gowda, Krishne, Peters, Jeffrey M., Amin, Shantu G., Perdew, Gary H.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2014
Teme:
Cellular and Molecular
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3912548/
https://ncbi.nlm.nih.gov/pubmed/24309559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.209726
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