Synthesis and SAR studies of dual AKT/NF-κB inhibitors against melanoma

The AKT and NF-κB pathways are central regulators of cellular signaling events at the basis of tumor development and progression. Both pathways are often up-regulated in different tumor types including melanoma. We recently reported the identification of compound 1 (BI-69A11) as inhibitor of the AKT...

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Bibliographic Details
Main Authors: Barile, Elisa, De, Surya K., Feng, Yongmei, Chen, Vida, Yang, Li, Ronai, Ze'ev, Pellecchia, Maurizio
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966491/
https://ncbi.nlm.nih.gov/pubmed/23790042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12177
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