Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate

Caspase-2 is an evolutionarily conserved but enigmatic protease whose biological role remains poorly understood. To date, research into the functions of caspase-2 has been hampered by an absence of reagents that can distinguish its activity from that of the downstream apoptotic caspase, caspase-3. I...

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Hlavní autoři: Kitevska, Tanja, Roberts, Sarah J., Pantaki-Eimany, Delara, Boyd, Sarah E., Scott, Fiona L., Hawkins, Christine J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2014
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3966047/
https://ncbi.nlm.nih.gov/pubmed/27919034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20140025
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