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Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate

Caspase-2 is an evolutionarily conserved but enigmatic protease whose biological role remains poorly understood. To date, research into the functions of caspase-2 has been hampered by an absence of reagents that can distinguish its activity from that of the downstream apoptotic caspase, caspase-3. I...

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Detalhes bibliográficos
Principais autores: Tanja Kitevska, Sarah J. Roberts, Delara Pantaki‑Eimany, Sarah E. Boyd, Fiona L. Scott, Christine J. Hawkins
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press, Biochemical Society 2014-03-01
coleção:Bioscience Reports
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Acesso em linha:http://www.bioscirep.org/bsr/034/e100/bsr034e100.htm
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