Role of the Lipoxygenase Pathway in RSV-induced Alternatively Activated Macrophages Leading to Resolution of Lung Pathology

Resolution of severe RSV-induced bronchiolitis is mediated by alternatively activated macrophages (AA-Mϕ) that counteract cyclooxygenase (COX)-2-induced lung pathology. Herein, we report that RSV infection of 5-lipoxygenase (LO)(−/−) and 15-LO(−/−) macrophages or mice failed to elicit AA-Mϕ differen...

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Detalhes bibliográficos
Main Authors: Shirey, Kari Ann, Lai, Wendy, Pletneva, Lioubov M., Karp, Christopher L., Divanovic, Senad, Blanco, Jorge C. G., Vogel, Stefanie N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965659/
https://ncbi.nlm.nih.gov/pubmed/24064666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.71
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