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A Recombinant Anchorless Respiratory Syncytial Virus (RSV) Fusion (F) Protein/Monophosphoryl Lipid A (MPL) Vaccine Protects against RSV-induced Replication and Lung Pathology
We previously demonstrated that the severe cytokine storm and pathology associated with RSV infection following intramuscular vaccination of cotton rats with FI-RSV Lot 100 could be completely abolished by formulating the vaccine with the mild TLR4 agonist and adjuvant, monophosphoryl lipid A (MPL)....
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3947896/ https://ncbi.nlm.nih.gov/pubmed/24252693 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2013.11.032 |
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