A Recombinant Anchorless Respiratory Syncytial Virus (RSV) Fusion (F) Protein/Monophosphoryl Lipid A (MPL) Vaccine Protects against RSV-induced Replication and Lung Pathology

We previously demonstrated that the severe cytokine storm and pathology associated with RSV infection following intramuscular vaccination of cotton rats with FI-RSV Lot 100 could be completely abolished by formulating the vaccine with the mild TLR4 agonist and adjuvant, monophosphoryl lipid A (MPL)....

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Main Authors: Blanco, Jorge C. G., Boukhvalova, Marina S., Pletneva, Lioubov M., Shirey, Kari Ann, Vogel, Stefanie N.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3947896/
https://ncbi.nlm.nih.gov/pubmed/24252693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2013.11.032
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