Respiratory Syncytial Virus Fusion Protein-Induced Toll-Like Receptor 4 (TLR4) Signaling Is Inhibited by the TLR4 Antagonists Rhodobacter sphaeroides Lipopolysaccharide and Eritoran (E5564) and Requires Direct Interaction with MD-2

Respiratory syncytial virus (RSV) is a leading cause of infant mortality worldwide. Toll-like receptor 4 (TLR4), a signaling receptor for structurally diverse microbe-associated molecular patterns, is activated by the RSV fusion (F) protein and by bacterial lipopolysaccharide (LPS) in a CD14-depende...

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Main Authors: Rallabhandi, Prasad, Phillips, Rachel L., Boukhvalova, Marina S., Pletneva, Lioubov M., Shirey, Kari Ann, Gioannini, Theresa L., Weiss, Jerrold P., Chow, Jesse C., Hawkins, Lynn D., Vogel, Stefanie N., Blanco, Jorge C. G.
格式: Artigo
語言:Inglês
出版: American Society of Microbiology 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419526/
https://ncbi.nlm.nih.gov/pubmed/22872782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00218-12
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