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Expression of Functional D299G.T399I Polymorphic Variant of TLR4 Depends More on Coexpression of MD-2 Than Does Wild-Type TLR4

Two missense variants (D299G and T399I) of TLR4 are cosegregated in individuals of European descent and, in a number of test systems, result in reduced responsiveness to endotoxin. How these changes within the ectodomain (ecd) of TLR4 affect TLR4 function is unclear. For both wild-type and D299G.T39...

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Detalhes bibliográficos
Main Authors: Prohinar, Polonca, Rallabhandi, Prasad, Weiss, Jerrold P., Gioannini, Theresa L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2881700/
https://ncbi.nlm.nih.gov/pubmed/20212095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0903142
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