Control of RSV-induced Lung Injury by Alternatively Activated Macrophages Is IL-4Rα-, TLR4-, and IFN-β-dependent

Severe RSV-induced bronchiolitis has been associated with a mixed “Th1” and “Th2” cytokine storm. We hypothesized that differentiation of “alternatively activated” macrophages (AA-Mϕ) would mediate resolution of RSV-induced lung injury. RSV induced IL-4 and IL-13 by murine lung and peritoneal macrop...

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Библиографические подробности
Главные авторы: Shirey, Kari Ann, Pletneva, Lioubov M., Puche, Adam C., Keegan, Achsah D., Prince, Gregory A., Blanco, Jorge C.G., Vogel, Stefanie N.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875872/
https://ncbi.nlm.nih.gov/pubmed/20404812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2010.6
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