Differences in amyloid-β clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modeling

Alzheimer’s disease (AD) has a characteristic hallmark of amyloid-β (Aβ) accumulation in the brain. This accumulation of Aβ has been related to its faulty cerebral clearance. Indeed, preclinical studies that used mice to investigate Aβ clearance showed that efflux across blood-brain barrier (BBB) an...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Qosa, Hisham, Abuasal, Bilal S., Romero, Ignacio A., Weksler, Babette, Couraud, Pierre-Oliver, Keller, Jeffrey N., Kaddoumi, Amal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965363/
https://ncbi.nlm.nih.gov/pubmed/24467845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.01.023
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky