Differences in amyloid-β clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modeling

Alzheimer’s disease (AD) has a characteristic hallmark of amyloid-β (Aβ) accumulation in the brain. This accumulation of Aβ has been related to its faulty cerebral clearance. Indeed, preclinical studies that used mice to investigate Aβ clearance showed that efflux across blood-brain barrier (BBB) an...

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Main Authors: Qosa, Hisham, Abuasal, Bilal S., Romero, Ignacio A., Weksler, Babette, Couraud, Pierre-Oliver, Keller, Jeffrey N., Kaddoumi, Amal
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965363/
https://ncbi.nlm.nih.gov/pubmed/24467845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.01.023
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