Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.

Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This therapy is based on the preferential phosphorylation of nucleoside analogs by tumor cells expressing HSV-1 thymidine kinase. However, the use of HSV-1 thymidine kinase is lim...

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Cyhoeddwyd yn:	Proc Natl Acad Sci U S A
Prif Awduron:	Black, M E, Newcomb, T G, Wilson, H M, Loeb, L A
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	National Academy of Sciences 1996
Pynciau:	Research Article
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8622970/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.8.3525
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