Bystander killing of cancer cells by herpes simplex virus thymidine kinase gene is mediated by connexins.
In gene therapy to treat cancer, typically only a fraction of the tumor cells can be successfully transfected with a gene. However, in the case of brain tumor therapy with the thymidine kinase gene from herpes simplex virus (HSV-tk), not only the cells transfected with the gene but also neighboring...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39867/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8700844/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.5.1831 |
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