Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This therapy is based on the preferential phosphorylation of nucleoside analogs by tumor cells expressing HSV-1 thymidine kinase. However, the use of HSV-1 thymidine kinase is lim...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1996
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8622970/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.8.3525 |
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